The Claymore sword was seen in the Hellsing OVA 8 episode where Alucard, in his form of Vlad the Impaler, used the sword when confronting Anderson in their final battle.

Alucard has demonstrated that he had excellent skill of handing the sword in offensive and defensive way of fighting. As an example, Alucard has deflected Anderson's full charge attack with ease. Another example is that Alucard used this sword throughout his human life during the 15th century, during the time when raging war with the Ottoman Turks thus making this sword his primary weapon over the centuries before the dual handguns during the present time .

In the manga, there's a chapter where Alucard remembered his past life as a prince of the Wallachia region of what is now modern day Romania and shows the developing hatred for the Ottoman Turks, later declaring full out war. In the end, the armies Alucard had died out, along with the Ottoman forces as well. It is shown in some of the pictures that Alucard used the sword with great success in battle.